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Noteworthy that while LY294002 and rapamycin down-regulated both IGF-1 and EE (but not testosterone) induced total MyHC (the sum of MyHC-F and -S isoforms), rapamycin could only suppress MyHC-F, but not MyHC-S isoform induced by EE (Fig
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“The vein is the express lane to your bloodstream,” as many infusion clinicians put it when explaining why IV routes act so quickly
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